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Sodium stibogluconate
Catalog No. T13013Cas No. 16037-91-5
Alias Stibogluconate trisodium nonahydrate
Sodium stibogluconate (Stibogluconate trisodium nonahydrate) is a potent inhibitor of protein tyrosine phosphatase.
Sodium stibogluconate
Catalog No. T13013Alias Stibogluconate trisodium nonahydrateCas No. 16037-91-5
Sodium stibogluconate (Stibogluconate trisodium nonahydrate) is a potent inhibitor of protein tyrosine phosphatase.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 100 mg | $49 | In Stock |
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Purity:99.95%
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All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.Product Introduction
Bioactivity
Chemical Properties
| Description | Sodium stibogluconate (Stibogluconate trisodium nonahydrate) is a potent inhibitor of protein tyrosine phosphatase. |
| In vitro | 99% of SHP-1 activity at 10 μg/mL inhibited by Sodium stibogluconate. Similar degrees of inhibition of SHP-2 and PTP1B required 100 μg/mL Sodium stibogluconate. The inhibition of cellular PTPases by the Sodium stibogluconate is suggested by its rapid induction of tyrosine phosphorylation of cellular proteins in Baf3 cells and its augmentation of IL-3-induced Janus family kinase 2/Stat5 tyrosine phosphorylation and proliferation of Baf3 cells. The augmentation of the opposite effects of GM-CSF and IFN-α on TF-1 cell growth by Sodium stibogluconate indicate its broad activities in the signaling of various cytokines[1]. |
| In vivo | Sodium stibogluconate induces 61% growth inhibition of Renca tumors in BALB/c mice coincident with an increase (2-fold) in tumor-infiltrating macrophages. A combination of Sodium stibogluconate and IL-2 is more effective in inhibiting tumor growth (91%) and inducing tumor-infiltrating (4-fold)[2]. |
| Alias | Stibogluconate trisodium nonahydrate |
| Molecular Weight | 907.88 |
| Formula | C12H35Na3O26Sb2 |
| Cas No. | 16037-91-5 |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||
| Solubility Information | H2O: 6.67 mg/mL (7.32 mM), when pH is adjusted to 3 with HCl. Sonication is recommended. DMSO: < 1 mg/mL (insoluble or slightly soluble) | |||||||||||||||
Solution Preparation Table | ||||||||||||||||
H2O
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(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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